- Author
-
P.R. Tuinman
- Title
- Experimental strategies directed at inflammation and coagulation in ARDS and TRALI
- Supervisors
-
M.J. Schultz
- Co-supervisors
-
N.P. Juffermans
- Award date
- 19 September 2013
- Number of pages
- 171
- ISBN
- 9789053357095
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
In this thesis, the effect of blood transfusion on pulmonary inflammation and coagulation was studied. We investigated the role of different mediators in acute respiratory distress syndrome (ARDS) or transfusion-related acute lung injury (TRALI). Furthermore, we tested several therapeutic strategies in murine models of both ARDS and TRALI. The effect of aspirin on TRALI incidence was tested. Lastly, we performed a systematic review on nebulized anticoagulants in the setting of lung injury in animals and humans.
- Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.397909
- Downloads
-
Thesis
Front cover
Title pages
Contents
Chapter 1: General introduction and outline of this thesis
Chapter 2: Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: A case-control study
Chapter 3: Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery
Chapter 4: Damage-associated molecular patterns in transfusion-related acute lung injury
Chapter 5: Methylprednisolone fails to attenuate lung injury in a mouse model of transfusion-related acute lung injury
Chapter 6: High-dose acetylsalicylic acid is superior to low dose as well as to clopidogrel in preventing LPS-induced lung injury in mice
Chapter 7: The effect of aspirin in transfusion-related acute lung injury in critically ill patients
Chapter 8: Lack of evidence of CD40Ligand involvement in transfusion-related acute lung injury
Chapter 9: Nebulized anticoagulants for acute lung injury: A systematic review of pre-clinical and clinical investigations
Chapter 10: Coagulopathy as a therapeutic target for TRALI: Rationale and possible sites of action
Chapter 11: Summary, general discussion and future directives
Chapter 12: Dutch summary for layman
Authors and affiliations
List of publications
Acknowledgements
Curriculum vitae
Stellingen
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