- Author
-
L.L. van Loendersloot
- Title
- Predicting IVF outcome
- Supervisors
-
F. van der Veen
P.M.M. Bossuyt - Co-supervisors
-
M. van Wely
S. Repping - Award date
- 3 December 2013
- Number of pages
- 194
- ISBN
- 9789461919335
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
On 25 July 1978 at 11.47 PM Louise Brown was born as the first IVF baby ever. Since its introduction more than 5 million babies have been born worldwide using IVF. In contrast to patients’ perception, IVF does not guarantee success; almost 50% of couples that start with IVF will not achieve a pregnancy through IVF even if they undergo multiple cycles. Given this limited success, it seems logical to offer IVF only to couples with reasonable chances of success and to discontinue treatment when chances are low and do not outweigh the burden and costs associated with treatment. As doctors are not able to correctly predict these pregnancy chances, prediction models can be a useful tool.
Another concern in current IVF practice is the high multiple pregnancy rates as multiple pregnancies are associated with an increase in maternal and perinatal morbidity and mortality as well as costs. A more individualized embryo transfer strategy could be a solution.
This PhD thesis describes the development and validation of several prediction models in IVF. The first part of this thesis focuses on couples’ prognosis with IVF. The second part of this thesis focuses on optimizing embryo transfer strategies. - Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.400222
- Downloads
-
Thesis
Front cover
Title pages
Contents
Chapter 1: Introduction
Chapter 2: The Templeton prediction model underestimates IVF success in an external validation
Chapter 3: Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis
Chapter 4: Individualized decision-making in IVF: calculating the chances of pregnancy
Chapter 5: Prediction models in in vitro fertilization; where are we?
Chapter 6: Pregnancy and twinning rates using a tailored embryo transfer policy
Chapter 7: Selection of embryos for transfer in IVF: ranking embryos based on their implantation potential using morphological scoring
Chapter 8: Balancing pregnancy and multiple pregnancy chances: an embryo transfer model
Chapter 9: Summary and implications for further research
Chapter 10: Samenvatting en implicaties voor toekomstig onderzoek
Portfolio
Dankwoord
About the author
Back cover
Stellingen
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