- Author
- Year
- 2014
- Title
- Serotonin receptor 3A controls interneuron migration into the neocortex
- Journal
- Nature Communications
- Volume
- 5
- Pages (from-to)
- 5524
- Number of pages
- 10
- Document type
- Article
- Faculty
- Faculty of Science (FNWI)
- Institute
- Swammerdam Institute for Life Sciences (SILS)
- Abstract
-
Neuronal excitability has been shown to control the migration and cortical integration of reelin-expressing cortical interneurons (INs) arising from the caudal ganglionic eminence (CGE), supporting the possibility that neurotransmitters could regulate this process. Here we show that the ionotropic serotonin receptor 3A (5-HT(3A)R) is specifically expressed in CGE-derived migrating interneurons and upregulated while they invade the developing cortex. Functional investigations using calcium imaging, electrophysiological recordings and migration assays indicate that CGE-derived INs increase their response to 5-HT(3A)R activation during the late phase of cortical plate invasion. Using genetic loss-of-function approaches and in vivo grafts, we further demonstrate that the 5-HT(3A)R is cell autonomously required for the migration and proper positioning of reelin-expressing CGE-derived INs in the neocortex. Our findings reveal a requirement for a serotonin receptor in controlling the migration and laminar positioning of a specific subtype of cortical IN.
- URL
- go to publisher's site
- Language
- English
- Note
- With supplementary information
- Persistent Identifier
- https://hdl.handle.net/11245/1.438927
- Downloads
-
Serotonin receptor 3A(Final published version)
- Supplementary materials
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