- Author
-
H.J.M.M. Mutsaerts
- Title
- Arterial spin labeling perfusion MRI: Inter-vendor reproducibility and clinical applicability
- Supervisors
-
C.B.L.M. Majoie
- Co-supervisors
-
A.J. Nederveen
- Award date
- 26 March 2015
- Number of pages
- 235
- ISBN
- 9789461825421
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Arterial spin labeling (ASL) is a perfusion magnetic resonance imaging (MRI) technique that non-invasively measures cerebral blood flow (CBF). The first part of this thesis concerns the inter-vendor reproducibility of ASL. Studies in this thesis show that on a total gray matter (GM) level, long-term physiological perfusion fluctuation dominates technical differences between ASL sequences and scanners. However, CBF data from smaller regions of interest were only comparable when sequences were made as identical as possible on different vendor MRI systems. Major effects include different readout modules, differences in effective post-labeling delay leading to differences in transit time sensitivity, the extent of the point spread function and the efficiency of background suppression. Furthermore, slight differences in sequence parameters can have a larger effect than differences in MRI hardware.
The second part of this thesis investigates several potential clinical applications of ASL. We show that white matter (WM) perfusion signal can be measured in the elderly, but also that the WM region of interest should be carefully eroded to avoid contamination with GM CBF. We demonstrate the statistical benefits of modest vascular crushing in a large population of elderly with hypertension. In the same population, WM lesion volume was correlated with WM lesion CBF but not with normal appearing WM or GM CBF. In children with sickle cell disease, we show correlations between CBF and hematological parameters that are both involved in the pathogenesis of WML and are key targets in the treatment of this disease. - Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.461986
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and outline
Chapter 2: Inter-vendor reproducibility of pseudo-continuous arterial spin labeling at 3 Tesla
Chapter 3: Reproducibility of pharmacological ASL using sequences from different vendors: Implications for multi-center drug studies
Chapter 4: Quantitative functional arterial spin labeling (fASL) MRI – sensitivity and reproducibility of regional CBF changes using pseudo-continuous ASL product sequences
Chapter 5: Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: implications for multi-center studies
Chapter 6: Gray matter contamination in arterial spin labeling white matter perfusion measurements in patients with dementia
Chapter 7: Cerebral perfusion measurements in the elderly using arterial spin labeling
Chapter 8: White matter hyperintensities in hypertension are not related to general perfusion deficits
Chapter 9: Risk factor analysis of cerebral white matter hyperintensities in children with sickle cell disease
Chapter 10: General discussion, conclusions and implications
Chapter 11: Summary
Appendix
Statements
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