- Author
-
O.A. Pougovkina
- Title
- Functional interplay between protein acylation and cellular metabolism in metabolic disorders
- Supervisors
-
R.J.A. Wanders
- Co-supervisors
-
V.C.J. de Boer
- Award date
- 20 January 2016
- Number of pages
- 159
- ISBN
- 9789462039728
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Lysine acylation is a rapidly growing field with a wide range of novel acylation modifications and a huge number of target proteins being identified. There are indications that these new modifications have functional roles in the regulation of cellular metabolism, however due to their novelty, little is known about the actual mechanisms. The aim of this thesis is to understand the physiological relevance of different protein acylation modifications in the regulation of cellular metabolism and to elucidate its role in inherited metabolic diseases.
- Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.505220
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation
Chapter 3: Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism
Chapter 4: Proteomic and biochemical studies of lysine malonylation suggests its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation
Chapter 5: The role of aberrant protein succinylation in Succinyl-CoA Synthetase deficiency
Chapter 6: Increased protein propionylation contributes to mitochondrial dysfunction in Propionyl-CoA carboxylase deficiency
Chapter 7: Discusion
Chapter 8: Summary / Samenvatting
Appendix
Stellingen behorende bij het proefschrift
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.