Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.
Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids
SCHETTINI, ROSARIAMembro del Collaboration Group
;COSTABILE, ChiaraMembro del Collaboration Group
;G. Della SalaMembro del Collaboration Group
;I. BrunoMembro del Collaboration Group
;DE RICCARDIS, FrancescoMembro del Collaboration Group
;I. Izzo
2018-01-01
Abstract
Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.File in questo prodotto:
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