Several new routes for the preparation of 3-amino-2-phenyl-4-1(H)-quinolinone 7a are compared. The most efficient is based on the cyclization of phenacyl anthranilamide 2a in the presence of (poly)phosphoric acid. The mechanisms of the rearrangements involved are discussed on the basis of the structures of isolated heterocyclic intermediates. The best methodology for the preparation of the title compound 7a was verified, and 10 other quinolinones 7 were prepared.
Some new routes for the preparation of 3-amino-2-phenyl-4(1H)-quinolinones from anthranilamides
BERTOLASI, Valerio
2006
Abstract
Several new routes for the preparation of 3-amino-2-phenyl-4-1(H)-quinolinone 7a are compared. The most efficient is based on the cyclization of phenacyl anthranilamide 2a in the presence of (poly)phosphoric acid. The mechanisms of the rearrangements involved are discussed on the basis of the structures of isolated heterocyclic intermediates. The best methodology for the preparation of the title compound 7a was verified, and 10 other quinolinones 7 were prepared.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
