The present work offers a brief overview about some innovative nanoparticulate delivery systems for dermal application. In particular solid lipid nanoparticles (SLN), ethosomes and cubosomes are presented as carrier systems alternative to liposomes. It has been demonstrated that that SLN can improve the controlled release of drugs, in addition in vivo studies performed by the use of SLN indicate an increase in skin hydration and a reduction in wrinkle depth. With regard to ethosomes, their soft structure enables facilitated delivery of the incorporated active agent into the skin lipid bilayers. The major potential of ethosomes in promoting penetration through skin with respect to liposomes is ascribed to the presence of ethanol and to the soft structure of the vesicles, promoting an interaction between ethosomes and skin lipids. Cubic liquid crystalline materials are an active research topic because their unique structure lends itself well to controlled release and skin care applications. Cubosomes usually have been produced by means of time-consuming methods involving high energy input. Conversely we have recently tested more conventional dispersion techniques demonstrating that the emulsification of monoglyceride/surfactant mixtures in water results in the formation of aqueous dispersions of cubosomes. Organoleptic and morphological features of cubosomes do not change by time, appearing free from phase-separation phenomena for almost 1 year from production. Photon Correlation Spectroscopy studies showed that cubosomes undergo an initial increase in mean diameter within the first month following production; afterwards they generally maintain their dimensions for the next 6 months.
Innovative nanotechnology based systems for dermal application
ESPOSITO, Elisabetta;MENEGATTI, Enea;CORTESI, Rita
2005
Abstract
The present work offers a brief overview about some innovative nanoparticulate delivery systems for dermal application. In particular solid lipid nanoparticles (SLN), ethosomes and cubosomes are presented as carrier systems alternative to liposomes. It has been demonstrated that that SLN can improve the controlled release of drugs, in addition in vivo studies performed by the use of SLN indicate an increase in skin hydration and a reduction in wrinkle depth. With regard to ethosomes, their soft structure enables facilitated delivery of the incorporated active agent into the skin lipid bilayers. The major potential of ethosomes in promoting penetration through skin with respect to liposomes is ascribed to the presence of ethanol and to the soft structure of the vesicles, promoting an interaction between ethosomes and skin lipids. Cubic liquid crystalline materials are an active research topic because their unique structure lends itself well to controlled release and skin care applications. Cubosomes usually have been produced by means of time-consuming methods involving high energy input. Conversely we have recently tested more conventional dispersion techniques demonstrating that the emulsification of monoglyceride/surfactant mixtures in water results in the formation of aqueous dispersions of cubosomes. Organoleptic and morphological features of cubosomes do not change by time, appearing free from phase-separation phenomena for almost 1 year from production. Photon Correlation Spectroscopy studies showed that cubosomes undergo an initial increase in mean diameter within the first month following production; afterwards they generally maintain their dimensions for the next 6 months.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
