The relationship between structure and specificity in the plant nitrilases
Doctoral Thesis
2011
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University of Cape Town
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Abstract
Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities.
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Reference:
Woodward, J. 2011. The relationship between structure and specificity in the plant nitrilases. University of Cape Town.