Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial
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Data
2013-12-31
Autores
Romao, Felipe Gazza [UNESP]
Campos, Elza Fernanda [UNESP]
Scabelo Mattoso, Claudio Roberto
Takahira, Regina Kiomi [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Biomed Central Ltd.
Resumo
Background: Thrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosuppressive effects. It is known that hypercortisolism can stimulate thrombi formation by increasing coagulation factors and decreasing fibrinolysis. However it is not known how prednisone administration affects hemostasis in dogs and if it is dose dependent. The aim of this study, therefore, was to demonstrate the effects of prednisone administration on dogs' hemostatic profile.Results: Significant decrease of antithrombin levels was observed in both groups (anti-inflammatory and immunosuppressive doses) after 15 days of treatment. An increase of platelet aggregation was observed in dogs receiving immunosuppressive doses of prednisone (Group II).Conclusions: From the results obtained in our study, it is not possible to infer that hypercortisolism can increase the thromboembolic risk, despite the decreased anticoagulant factors (antithrombin levels).
Descrição
Palavras-chave
Platelets, Hemostasis, Prednisone, Thromboembolism
Como citar
Bmc Veterinary Research. London: Biomed Central Ltd, v. 9, 6 p., 2013.