Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

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Data

2014-05-01

Autores

Chapla, Vanessa Mara [UNESP]
Zeraik, Maria Luiza [UNESP]
Ximenes, Valdecir F. [UNESP]
Zanardi, Lisineia Maria [UNESP]
Lopes, Márcia Nasser [UNESP]
Cavalheiro, Alberto José [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
Young, Maria Claudia M.
Fonseca, Luiz Marcos da [UNESP]
Bolzani, Vanderlan da Silva [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Mdpi Ag

Resumo

Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.

Descrição

Palavras-chave

secondary metabolites, bioactivities, endophytic fungi, Phomopsis sp., Senna spectabilis

Como citar

Molecules. Basel: Mdpi Ag, v. 19, n. 5, p. 6597-6608, 2014.