Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
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Data
2014-05-01
Autores
Chapla, Vanessa Mara [UNESP]
Zeraik, Maria Luiza [UNESP]
Ximenes, Valdecir F. [UNESP]
Zanardi, Lisineia Maria [UNESP]
Lopes, Márcia Nasser [UNESP]
Cavalheiro, Alberto José [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
Young, Maria Claudia M.
Fonseca, Luiz Marcos da [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Mdpi Ag
Resumo
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.
Descrição
Palavras-chave
secondary metabolites, bioactivities, endophytic fungi, Phomopsis sp., Senna spectabilis
Como citar
Molecules. Basel: Mdpi Ag, v. 19, n. 5, p. 6597-6608, 2014.