Experimental infection of inbred BALB/c and A/J mice with Massachusetts and Brazilian strains of infectious bronchitis virus (IBV)
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Data
2015-07-01
Autores
Martini, Matheus Cavalheiro
Gameiro, Jacy
Cardoso, Tereza Cristina [UNESP]
Caserta, Leonardo Cardia
Gualberto, Ana Carolina
Keid, Lara Borges
Oliveira, Tricia Maria Ferreira de Sousa
Santos, Márcia Mercês Aparecida Bianchi dos
Arns, Clarice Weis
Ferreira, Helena Lage
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Editor
Springer
Resumo
The ability of avian coronaviruses to replicate in mice was investigated to investigate interspecies transmission. Two inbred mouse strains (BALB/c and A/J) with different genetic backgrounds were inoculated with the avian coronavirus strains Mass and BR-I and monitored for at least 10 days. Analysis of viral RNA, histopathological examinations, immunohistochemistry and serology were performed. After virus inoculation, neither clinical signs nor evident gross lesions were observed. Viral RNA, histopathological changes, and viral nucleoprotein were observed in the lung, trachea and sinus of all inoculated mice. Our study demonstrates the importance of elucidating the epidemiology of coronaviruses, including in rodents that are pests in poultry production.
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Palavras-chave
Virus, Mice, Avian, Pneumonia
Como citar
Archives Of Virology. Wien: Springer Wien, v. 160, n. 7, p. 1785-1790, 2015.