Interação célula hospedeira e a infecção pelo herpesvirus bovino 5 (BHV5)
Carregando...
Data
2017-02-24
Autores
Okamura, Lucas Hidenori [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
O Brasil possui um dos maiores rebanhos de bovinos mundialmente. Estes animais estão expostos constantemente a agentes virais causadores de patologias. Dentre estes, o herpesvírus bovino 1 (BHV1) e 5 (BHV5) apresentam grande importância epidemiológica. O BHV1 causa infecções respiratórias e genitais, enquanto que o BHV5 meningoencefalite. As proteínas de membrana presentes nos herpesvírus os tornam capazes de infectar as células do hospedeiro. Com afinidade a distintas células, desenvolvem sua capacidade de infecção, apresentam mecanismos de sobrevivência à morte celular programada e a resposta imunológica. As interações vírus-hospedeiro são fundamentais no entendimento de aspectos relacionados a transmissão viral, capacidade de infecção e progressão da doença. Para este fim, se faz necessário compreender elementos fundamentais, como a modulação da função mitocondrial e a replicação do BHV, bem como os níveis de apoptose nas células do hospedeiro. De igual importância, é indispensável entender o comportamento de genes apoptóticos que estão relacionados à infecção por BHV5 e seus envolvimentos na viabilidade celular. Estes achados contribuem para o entendimento da imunopatogenia do BHV, auxiliam a evitar a disseminação destes agentes e são de grande valia para o desenvolvimento de vacinas.
Brazil has one of the largest cattle hers worldwide. These animals are constantly exposed to pathological viral agents. Bovine herpesvirus 1 (BHV1) and BHV5 have great epidemiological importance. BHV1 is causative agent of respiratory and genital infections, while BHV5 causes meningoencephalitis. Herpesvirus membrane proteins allow them to infect the host cells. They present affinity to different types of cells, develop mechanisms to survive programmed cell death, and immune response. Virus-host interactions are essential to understand aspects related to viral transmission, capacity of infection and disease progression. To this end, it is necessary to understand the fundamental elements related to the modulation of mitochondrial function and replication of BHV, as well as apoptosis levels in the host cells. It is crucial to understand the behavior of apoptotic genes related to BHV5 infection and cell viability. These findings contribute to understanding the BHV immunopathogenesis, help to prevent the spread of these agents, and are of great value to the development of vaccines.
Brazil has one of the largest cattle hers worldwide. These animals are constantly exposed to pathological viral agents. Bovine herpesvirus 1 (BHV1) and BHV5 have great epidemiological importance. BHV1 is causative agent of respiratory and genital infections, while BHV5 causes meningoencephalitis. Herpesvirus membrane proteins allow them to infect the host cells. They present affinity to different types of cells, develop mechanisms to survive programmed cell death, and immune response. Virus-host interactions are essential to understand aspects related to viral transmission, capacity of infection and disease progression. To this end, it is necessary to understand the fundamental elements related to the modulation of mitochondrial function and replication of BHV, as well as apoptosis levels in the host cells. It is crucial to understand the behavior of apoptotic genes related to BHV5 infection and cell viability. These findings contribute to understanding the BHV immunopathogenesis, help to prevent the spread of these agents, and are of great value to the development of vaccines.
Descrição
Palavras-chave
Microbiologia veterinária, Bovino, Virologia veterinária, Vírus do herpes em animais, Morte celular, Apoptose