Avaliação do impacto de nanofibras de celulose na obtenção de filmes de amido retrogradado para liberação colônica do 5-ASA
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Data
2021-12-13
Autores
Nunes, Sara Peres
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Universidade Estadual Paulista (Unesp)
Resumo
Apesar da pectina proporcionar boas propriedades filmógenas somada ao amido retrogradado, seu nível de solubilidade pode ocasionar liberação prematura de fármaco quando esta faz parte de um sistema de liberação cólon-específico. Devido a isso, a inserção da nanofibra de celulose (NFC) na matriz polimérica pode gerar um nanoreforço, que auxilia nas propriedades mecânicas, filmógenas e na performance dos filmes formados, para contribuir com o carreamento do fármaco 5-ASA. Os filmes obtidos pelo processo de solvente casting apresentaram boa integridade e maleabilidade. Nas imagens obtidas por MEV, de maneira geral, os filmes mostram-se com uma superfície contínua e seção transversal bem estruturada. As propriedades mecânicas de resistência à perfuração (Rp), alongamento durante à perfuração (Ap) e energia na perfuração (Ep) mostraram que o aumento da concentração de NFC favoreceu essas características. O ensaio de mucoadesão mostrou que o uso de NFC promove uma boa força de mucoadesão, o que indica notável interação com a mucina presente no muco. O teste de absorção de líquidos revela que o uso da NFC contribui para diminuir o intumescimento dos filmes em meio ácido. Apesar disso, ainda houve liberação de fármaco no meio gástrico simulado, de acordo com o teste de liberação.
Although pectin provides good film-forming properties with retrograde starch, its solubility level can lead to premature drug release when it is part of a colon-specific delivery system. Due to this, the insertion of cellulose nanofiber (CNF) in the polymeric matrix can generate a nanoreinforcement, which helps in the mechanical and film-forming properties and in the performance of the formed films, to contribute to the 5-ASA drug delivery. The films obtained by the solvent casting process show good integrity and malleability. In the images presented by SEM, in general, the films are shown with a continuous surface and a well-structured cross section. The mechanical properties of resistance to perforation (Rp), elongation during perforation (Ap) and energy in perforation (Ep) showed that the increase in the concentration of CNF favored these characteristics. The mucoadhesion test revealed that the use of CNF promotes good mucoadhesion strength, which indicates a remarkable interaction with the mucin present in the mucus. The liquid absorption test shows that the use of CNF helps to reduce the swelling of films in an acidic environment. Despite this, there was still drug release in the simulated gastric environment, according to the release test.
Although pectin provides good film-forming properties with retrograde starch, its solubility level can lead to premature drug release when it is part of a colon-specific delivery system. Due to this, the insertion of cellulose nanofiber (CNF) in the polymeric matrix can generate a nanoreinforcement, which helps in the mechanical and film-forming properties and in the performance of the formed films, to contribute to the 5-ASA drug delivery. The films obtained by the solvent casting process show good integrity and malleability. In the images presented by SEM, in general, the films are shown with a continuous surface and a well-structured cross section. The mechanical properties of resistance to perforation (Rp), elongation during perforation (Ap) and energy in perforation (Ep) showed that the increase in the concentration of CNF favored these characteristics. The mucoadhesion test revealed that the use of CNF promotes good mucoadhesion strength, which indicates a remarkable interaction with the mucin present in the mucus. The liquid absorption test shows that the use of CNF helps to reduce the swelling of films in an acidic environment. Despite this, there was still drug release in the simulated gastric environment, according to the release test.
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Palavras-chave
Amido retrogradado, Nanofibras de celulose, Filmes poliméricos, 5-ASA, Liberação cólon-específica