Melanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area
Carregando...
Data
2022
Autores
Dias, Mirela B. [UNESP]
Gargaglioni, Luciane H [UNESP]
Patrone, Luis G.A. [UNESP]
Rodrigues, LaĆsa TC
TĆtulo da Revista
ISSN da Revista
TĆtulo de Volume
Editor
Resumo
DescriĆ§Ć£o
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide involved in a broad range of homeostatic functions including regulation of the hypercapnic chemoreflex. We evaluated whether MCH modulates the hypercapnic ventilatory response by acting in the lateral hypothalamic area (LHA) and/or in the locus coeruleus (LC). Here, we measured pulmonary ventilation ( E), body temperature, EEG and EMG of unanesthetized male Wistar rats before and after microinjection of MCH [0.4 mM] into the LHA and LC, or the MCH1-R antagonist (SNAP-94847 [63 mM]), into the LHA, in room air and in 7% CO2 during wakefulness and sleep, in the dark and light periods. MCH intra-LHA caused a decreased CO2 ventilatory response during wakefulness and sleep, while SNAP-94847 intra-LHA increased this response, during wakefulness in the light period. In the LC, MCH or the MCH1-R antagonist caused no change in the hypercapnic ventilatory response. Our results suggest that MCH, in the LHA, exerts an inhibitory modulation of the hypercapnic ventilatory response during the light-inactive period in rats.
Palavras-chave
Breathing, Chemoreceptors, Hypothalamus, Breathing