Anatomia patológica comparada – viabilidade da utilização da classificação anatomopatológica humana de osteossarcoma apendicular em caninos (canis familiaris).
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Data
2023-03-31
Autores
Gomes, Marcela da Costa
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Universidade Estadual Paulista (Unesp)
Resumo
O osteossarcoma (OSA) representa de 80 a 85% dos tumores malignos ósseos de cães, sendo uma das neoplasias com comportamento de maior agressividade na espécie, semelhante ao que ocorre nos seres humanos em crianças e adolescentes. Os sistemas de classificação e graduação histopatológicos humanos de tumores ósseos, no entanto, estão mais amplamente consolidados do que os veterinários. O objetivo geral do trabalho foi realizar a comparação entre os sistemas de classificação e graduação histopatológicos estabelecidos pela Organização Mundial da Saúde tanto humanos quanto veterinários, e assim verificar as diferenças e as semelhanças anatomopatológicas da neoplasia nas duas espécies. O marcador anti Ki-67 determinou o índice de proliferação celular. Foi realizada pesquisa retrospectiva e prospectiva em peças cirúrgicas de tumores ósseos em membros apendiculares caninos do Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecnia/ UNESP, campus de Botucatu, São Paulo. Os diagnósticos obtidos através das classificações e graduações humana e animal foram transformados em proporções dividindo-se a quantia individual pela quantia total e comparadas com teste Chi-quadrado, pelo programa Bioestat. A graduação de osteossarcoma pelo sistema humano resultou em grau I (20,8%), grau II (39,6%), grau III (22,6%) e grau IV (17,0%). Já a graduação pelo sistema veterinário resultou em grau I (90,6%) e grau II (9,4%). Foram comparadas as tabelas de tipificação histológica humana e veterinária pelo teste Chi-quadrado, resultando em p=0,7373, ou seja, não houve diferença estatística significante. Também foram comparadas as tabelas de graduação tumoral humana e veterinária, resultando em p<0,001, ou seja, havendo diferença estatística significante. A princípio, não há, para esta amostra, aplicabilidade da graduação tumoral humana nos tumores ósseos apendiculares primários caninos.
Osteosarcoma (OSA) represents 80 to 85% of malignant bone tumors in dogs, being one of the neoplasms with the most aggressive behavior in the species, similar to what occurs in humans, allowing comparative studies between the two species. The human histopathological classification and grading systems of bone tumors, however, are more widely consolidated than the veterinary ones. This is because the former provide greater clinical value and more efficiently establish the prognostic value for osteosarcomas in humans. The general objective of this study was to compare the histopathological classification and grading systems established by the World Health Organization for both humans and veterinarians, and thus verify the pathological differences and similarities of the neoplasia in both species. The anti Ki-67 marker determined the cell proliferation index, serving as a comparative tool between classifications. . A retrospective and prospective study was carried out on surgical specimens of bone tumors in canine appendicular limbs at the Veterinary Hospital of the Faculty of Veterinary Medicine and Animal Science/UNESP, Botucatu campus, São Paulo. The diagnoses obtained through the human and animal classifications and graduations were transformed into proportions by dividing the individual amount by the total amount and compared with the Chi-square test, using the Bioestat program. Grading of osteosarcoma by the human system resulted in grade I (20.8%), grade II (39.6%), grade III (22.6%) and grade IV (17.0%). Graduation through the veterinary system resulted in grade I (90.6%) and grade II (9.4%). The human and veterinary histological typification tables were compared using the Chi-square test, resulting in p=0.7373, that is, there was no statistically significant difference. The human and veterinary tumor grading tables were also compared, resulting in p<0.001, that is, there was a statistically significant difference. At first, for this sample, there is no applicability of human tumor grading in canine primary appendicular bone tumors.
Osteosarcoma (OSA) represents 80 to 85% of malignant bone tumors in dogs, being one of the neoplasms with the most aggressive behavior in the species, similar to what occurs in humans, allowing comparative studies between the two species. The human histopathological classification and grading systems of bone tumors, however, are more widely consolidated than the veterinary ones. This is because the former provide greater clinical value and more efficiently establish the prognostic value for osteosarcomas in humans. The general objective of this study was to compare the histopathological classification and grading systems established by the World Health Organization for both humans and veterinarians, and thus verify the pathological differences and similarities of the neoplasia in both species. The anti Ki-67 marker determined the cell proliferation index, serving as a comparative tool between classifications. . A retrospective and prospective study was carried out on surgical specimens of bone tumors in canine appendicular limbs at the Veterinary Hospital of the Faculty of Veterinary Medicine and Animal Science/UNESP, Botucatu campus, São Paulo. The diagnoses obtained through the human and animal classifications and graduations were transformed into proportions by dividing the individual amount by the total amount and compared with the Chi-square test, using the Bioestat program. Grading of osteosarcoma by the human system resulted in grade I (20.8%), grade II (39.6%), grade III (22.6%) and grade IV (17.0%). Graduation through the veterinary system resulted in grade I (90.6%) and grade II (9.4%). The human and veterinary histological typification tables were compared using the Chi-square test, resulting in p=0.7373, that is, there was no statistically significant difference. The human and veterinary tumor grading tables were also compared, resulting in p<0.001, that is, there was a statistically significant difference. At first, for this sample, there is no applicability of human tumor grading in canine primary appendicular bone tumors.
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Palavras-chave
Neoplasia óssea, Cão, Histopatologia veterinária, Patologia comparada, Imunofenotipagem, Ki-67, Osteossarcoma