Considerações sobre o câncer localmente avançado de mama (CLAM) acrescidas de identificação dos receptores de estrogênios usando anticorpos monoclonais.
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Data
1993-01-01
Autores
de Luca, L. A.
Schmitt, F. C.
Traiman, Paulo [UNESP]
Oliveira Júnior, Batista de [UNESP]
Andrade, Luís Gustavo Modelli de [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Lunardi, M. T.
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Resumo
The effects of therapy in locally advanced breast cancer submitted to combined conventional telecobalt therapy plus chemotherapy with cyclophosphamide and 5-fluorouracil were studied in 49 patients. Associated to radical mastectomy in operable cases. Local tumor control was achieved in 86.7%. There were no local recurrences in those submitted to surgery but they reached 21.7% in inoperable patients who received only radiation therapy and chemotherapy. The median follow-up time for dead patients was 29.5 months and for living patients 79.3 months. The index of complete responses was 24.5% and the median disease free interval was 22.9 months. The overall survival rate, between three and five years, was 32.7%. Estrogen receptors were identified by using immunohistochemical assay ER-ICA and monoclonal antibody H222-SP gamma, Abbott. There were no differences in the complete response index, disease free interval and survival rates, among ER-positive and ER-negative patients, explained by the far advanced stage of the disease. ER-positivity was significantly correlated with histological features of the tumors: cell differentiation, presence of elastosis, absence of lymphocytic infiltration and absence of tumor necrosis.
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Palavras-chave
estrogen receptor, monoclonal antibody, adult, aged, breast tumor, cancer staging, chemistry, comparative study, female, human, mortality, multimodality cancer therapy, pathology, prognosis, retrospective study, review, tumor recurrence, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Breast Neoplasms, Combined Modality Therapy, Comparative Study, English Abstract, Female, Human, Middle Age, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Receptors, Estrogen, Retrospective Studies
Como citar
Revista da Associacao Medica Brasileira (1992), v. 39, n. 1, p. 17-32, 1993.