Bioactive guanidine alkaloids from Pterogyne nitens

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Data

1995-12-01

Autores

Bolzani, Vanderlan da Silva [UNESP]
Gunatilaka, A. A. Leslie
Kingston, David G. I.

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Resumo

Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).

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Palavras-chave

guanidine derivative, nitensidine, pterogynidine, pterogynine, unclassified drug, antineoplastic activity, bioassay, carbon nuclear magnetic resonance, cytotoxicity, dna repair, drug activity, drug isolation, drug structure, proton nuclear magnetic resonance

Como citar

Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.