Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis
Date
2011-11-20
Authors
Yılmaz, Yusuf
Eren, Fatih
Çolak, Yaşar
Kurt, Ramazan
Şenateş, Ebubekir
Tuncer, İlyas
İmeryuz, Neşe
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Background: Increased serum concentrations of pigment epithelium-derived factor (PEDF) have been linked to the metabolic syndrome in the general population. However, the relationship between serum PEDF and nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, remains unknown.
Methods: We assayed serum PEDF levels in 156 patients with biopsy-proven NAFLD and 103 nonsteatotic control subjects who were matched for age and sex. The association between levels of PEDF and clinical, biochemical, and histological phenotypes was examined.
Results: NAFLD patients had significantly higher serum PEDF levels (1.97 +/- 0.50 mu g/mL) than control subjects (1.51 +/- 0.49 mu g/mL, Student's t test, P<0.001). Multivariable-adjusted stepwise regression analysis showed that PEDF ([beta] = 0.32, t = 3.13, P = 0.002) and triglycerides ([beta] = 0.22, t = 2.23. P = 0.02) were, in the order they entered into the model, the main independent predictors of steatosis scores in our patients with NAFLD.
Conclusions: Serum PEDF levels are significantly increased in patients with biopsy-proven NAFLD and are associated with liver steatosis independently of traditional risk factors.
Description
Keywords
Medical laboratory technology, Pigment epithelium-derived factor, Nonalcoholic fatty liver disease, Enzyme-linked immunosorbent assay, Steatosis, Endothelial growth-factor, Factor pedf, Metabolic syndrome, Insulin-resistance, Angiogenesis, Activation, Cells
Citation
Yılmaz, Y. vd. (2011). ''Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis''. Clinica Chimica Acta, 412(23-24), 2296-2299.