A case of interstitial lung granulomas is described in a worker exposed to zirconium compounds. Chest X-rays revealed diffuse slight reticular interstitial radiopacities (ILO classification, 1/0 s/t). Histological examination of transbronchial biopsy tissue revealed small interstitial non-confluent granulomas with epithelioid and giant cells showing no central necrosis, with PAS-positive diastase-resistant small weakly birefringent particles in interstitial histiocytes. These histological and stain findings, which are characteristic of zirconium skin lesions and granulomas, suggest zirconium interstitial lung disease.
Interstitial lung granulomas as a possible consequence of exposure to zirconium dust
CAZZADORI, Angelo Antonio;
1994-01-01
Abstract
A case of interstitial lung granulomas is described in a worker exposed to zirconium compounds. Chest X-rays revealed diffuse slight reticular interstitial radiopacities (ILO classification, 1/0 s/t). Histological examination of transbronchial biopsy tissue revealed small interstitial non-confluent granulomas with epithelioid and giant cells showing no central necrosis, with PAS-positive diastase-resistant small weakly birefringent particles in interstitial histiocytes. These histological and stain findings, which are characteristic of zirconium skin lesions and granulomas, suggest zirconium interstitial lung disease.
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