Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc.

First-generation antipsychotics and QTc: any role for mediating variables?

NOSE', Michela;Bighelli, Irene;OSTUZZI, Giovanni;CASTELLAZZI, Mariasole;BARBUI, Corrado;
2016-01-01

Abstract

Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc.
2016
QT prolongation; alcohol; antipsychotic agents; drug therapy combination; risk factors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/948414
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