As a part of an ongoing search for new isoniazid-related isonicotinoylhydrazones (ISNEs), 2'-monosubstituted isonicotinohydrazides and cyanoboranes, some analogues belonging to these three series of compounds were further evaluated in an in vitro advanced antimycobacterial screening. The results here reported allowed us to extend their structure-activity relationships. A general correlation emerged between their lipophilicity and effectiveness against intracellular M. tuberculosis. On the whole, the most interesting result of this research was that some hydrazides and ISNEs proved to be more effective antimycobacterial agents than parental isoniazid in a TB-infected macrophage model.

In vitro advanced antimycobacterial screening of isoniazid-related hydrazones, hydrazides and cyanoboranes: Part 14

MACCARI, Rosanna;OTTANA', Rosaria;VIGORITA, Maria
2005-01-01

Abstract

As a part of an ongoing search for new isoniazid-related isonicotinoylhydrazones (ISNEs), 2'-monosubstituted isonicotinohydrazides and cyanoboranes, some analogues belonging to these three series of compounds were further evaluated in an in vitro advanced antimycobacterial screening. The results here reported allowed us to extend their structure-activity relationships. A general correlation emerged between their lipophilicity and effectiveness against intracellular M. tuberculosis. On the whole, the most interesting result of this research was that some hydrazides and ISNEs proved to be more effective antimycobacterial agents than parental isoniazid in a TB-infected macrophage model.
2005
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1434150
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 28
  • Scopus 153
  • ???jsp.display-item.citation.isi??? ND
social impact