The Cyclic Alternating Pattern (CAP) is a physiological oscillatory activity consisting of repetitive sequences of activation phase (A) and inhibitory phase (B) during NREM sleep, expressing a state of sleep instability (arousal), which was documented to modulate most of the paroxysmal epileptic events during sleep. Macro- and microstructure (CAP) of sleep was analized in 14 laboratory or ambulatory Polysomnographic (PSG) recordings of 12 adult patients affected by symptomatic or cryptogenic localization-related epilepsy. Forty-four out of the 56 seizures recorded (78%) occurred during a CAP sequence, in close relation to A (namely A2) phase. Fifty-five per cent of the seizures was followed by awakening; 62% of the seizures occurring during non-CAP sleep was followed by CAP. The A phase of CAP appears to be a trigger for most of the seizures recorded independently of the macrostructural stage of NREM sleep. In turn the seizure occurrence results in sleep fragmentation.
Relation between arousal and focal epileptic seizure during sleep: Evaluation by CAP analysis
Manni R.;Terzaghi M.;Galimberti C. A.;Rustioni V.;Marchese D.
2003-01-01
Abstract
The Cyclic Alternating Pattern (CAP) is a physiological oscillatory activity consisting of repetitive sequences of activation phase (A) and inhibitory phase (B) during NREM sleep, expressing a state of sleep instability (arousal), which was documented to modulate most of the paroxysmal epileptic events during sleep. Macro- and microstructure (CAP) of sleep was analized in 14 laboratory or ambulatory Polysomnographic (PSG) recordings of 12 adult patients affected by symptomatic or cryptogenic localization-related epilepsy. Forty-four out of the 56 seizures recorded (78%) occurred during a CAP sequence, in close relation to A (namely A2) phase. Fifty-five per cent of the seizures was followed by awakening; 62% of the seizures occurring during non-CAP sleep was followed by CAP. The A phase of CAP appears to be a trigger for most of the seizures recorded independently of the macrostructural stage of NREM sleep. In turn the seizure occurrence results in sleep fragmentation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
