Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexist- ing glomerulonephritis. We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Nasal endoscopy showed a large nasal septum perforation and an anterior translucid mass in the right nasal fossa. Findings were confirmed by computed tomography (CT) scan with contrast. The patient underwent func- tional transnasal endoscopic removal of the mass; histological examination showed tissue features suggestive of GPA; dosage of c-ANCA e p-ANCA antibodies confirmed GPA diagnosis. Nasal septum perforation has long been recognized as a feature of GPA, in which granulomatous destruction of nasal cartilage can result in perforation and saddle-nose deformity. Prompt diagno- sis of GPA is important to initiate therapy which may be life-saving and organ sparing.
Nasal manifestations in granulomatosis with polyangiitis: a case report and review of the literature / Ralli, Massimo; D'Aguanno, Vittorio; Falasca, Vincenzo; Turchetta, Rosaria; Greco, Antonio; DE VINCENTIIS, Marco. - In: OTOLARYNGOLOGY OPEN ACCESS JOURNAL. - ISSN 2476-2490. - 4:1(2018), pp. 22-25. [10.17140/OTLOJ-4-149]
Nasal manifestations in granulomatosis with polyangiitis: a case report and review of the literature
Massimo Ralli
Primo
;Vittorio D’ AguannoSecondo
;Vincenzo Falasca;Rosaria Turchetta;Antonio GrecoPenultimo
;Marco de VincentiisUltimo
2018
Abstract
Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexist- ing glomerulonephritis. We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Nasal endoscopy showed a large nasal septum perforation and an anterior translucid mass in the right nasal fossa. Findings were confirmed by computed tomography (CT) scan with contrast. The patient underwent func- tional transnasal endoscopic removal of the mass; histological examination showed tissue features suggestive of GPA; dosage of c-ANCA e p-ANCA antibodies confirmed GPA diagnosis. Nasal septum perforation has long been recognized as a feature of GPA, in which granulomatous destruction of nasal cartilage can result in perforation and saddle-nose deformity. Prompt diagno- sis of GPA is important to initiate therapy which may be life-saving and organ sparing.File | Dimensione | Formato | |
---|---|---|---|
Ralli_Nasal_2018.pdf
accesso aperto
Note: https://openventio.org/nasal-manifestations-in-granulomatosis-with-polyangiitis-a-case-report-and-review-of-the-literature/
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
446.2 kB
Formato
Adobe PDF
|
446.2 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.