As a preventive strategy to inhibit fungal biofilm formation on medical devices, we planned experiments based on polyurethane loading with fluconazole plus pore-former agents in order to obtain a promoted release of the antifungal drug. Different functional groups including carboxyl, hydroxyl, primary and tertiary amino groups, were introduced in polyurethanes. Fluconazole was adsorbed in higher amounts by the most hydrophilic polymers and its release was influenced by the degree of polymer swelling in water. The entrapping in the polymer of polyethylenglycol as a pore former significantly improved the fluconazole release while the entrapping of the higher molecular weight porogen albumin resulted in a controlled drug release and in an improved antifungal activity over time. Among the tested in vitro models, best results were achieved with an hydrophobic polymer impregnated with 25% (w/w) albumin and fluconazole which inhibited Candida albicans growth and biofilm formation on polymeric surfaces up to 8 days.

Pore formers promoted release of an antifungal drug from functionalized polyurethanes to inhibit Candida colonization / G., Donelli; Francolini, Iolanda; Ruggeri, Valeria; E., Guaglianone; D'Ilario, Lucio; Piozzi, Antonella. - In: JOURNAL OF APPLIED MICROBIOLOGY. - ISSN 1364-5072. - STAMPA. - 100:3(2006), pp. 615-622. [10.1111/j.1365-2672.2005.02801.x]

Pore formers promoted release of an antifungal drug from functionalized polyurethanes to inhibit Candida colonization

FRANCOLINI, IOLANDA;RUGGERI, VALERIA;D'ILARIO, LUCIO;PIOZZI, Antonella
2006

Abstract

As a preventive strategy to inhibit fungal biofilm formation on medical devices, we planned experiments based on polyurethane loading with fluconazole plus pore-former agents in order to obtain a promoted release of the antifungal drug. Different functional groups including carboxyl, hydroxyl, primary and tertiary amino groups, were introduced in polyurethanes. Fluconazole was adsorbed in higher amounts by the most hydrophilic polymers and its release was influenced by the degree of polymer swelling in water. The entrapping in the polymer of polyethylenglycol as a pore former significantly improved the fluconazole release while the entrapping of the higher molecular weight porogen albumin resulted in a controlled drug release and in an improved antifungal activity over time. Among the tested in vitro models, best results were achieved with an hydrophobic polymer impregnated with 25% (w/w) albumin and fluconazole which inhibited Candida albicans growth and biofilm formation on polymeric surfaces up to 8 days.
2006
albumin; biofilms; candida; fluconazole; medical; medical devices; polyethylenglycol; polyurethanes
01 Pubblicazione su rivista::01a Articolo in rivista
Pore formers promoted release of an antifungal drug from functionalized polyurethanes to inhibit Candida colonization / G., Donelli; Francolini, Iolanda; Ruggeri, Valeria; E., Guaglianone; D'Ilario, Lucio; Piozzi, Antonella. - In: JOURNAL OF APPLIED MICROBIOLOGY. - ISSN 1364-5072. - STAMPA. - 100:3(2006), pp. 615-622. [10.1111/j.1365-2672.2005.02801.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/231357
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