Pyrrolo[1,2-b][1,2,5]benzothiadiazepine 5,5-dioxides (PBTDs) induced apoptosis in human BCR-ABL-expressing leukemia cells. The apoptotic activity was also observed in primary leukemic blasts, obtained from chronic myelogenous leukemia (CML) patients at onset or from patients in blast crisis and who were imatinib-resistant. Compounds 5 and 14 induced apoptosis before BCR-ABL protein expression and tyrosin phosphorylation were affected and activated different caspases in the apoptotic pathway. PBTDs are a new class of valid candidates for the treatment of CML.

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant / Silvestri, Romano; Marfe', G.; Artico, Marino; LA REGINA, Giuseppe; LA VECCHIA, A.; Novellino, E.; Morgante, E.; DI STEFANO, C.; Catalano, G.; Filomeni, G.; Abruzzese, E.; Ciriolo, M. R.; Russo, M.; Amadori, S.; Birilli, R.; LA TORRE, F.; SINIBALDI SOLIMEI, P.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 49:(2006), pp. 5840-5844. [10.1021/jm0602716]

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant.

SILVESTRI, Romano;ARTICO, Marino;LA REGINA, GIUSEPPE;LA TORRE F.;
2006

Abstract

Pyrrolo[1,2-b][1,2,5]benzothiadiazepine 5,5-dioxides (PBTDs) induced apoptosis in human BCR-ABL-expressing leukemia cells. The apoptotic activity was also observed in primary leukemic blasts, obtained from chronic myelogenous leukemia (CML) patients at onset or from patients in blast crisis and who were imatinib-resistant. Compounds 5 and 14 induced apoptosis before BCR-ABL protein expression and tyrosin phosphorylation were affected and activated different caspases in the apoptotic pathway. PBTDs are a new class of valid candidates for the treatment of CML.
2006
01 Pubblicazione su rivista::01a Articolo in rivista
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant / Silvestri, Romano; Marfe', G.; Artico, Marino; LA REGINA, Giuseppe; LA VECCHIA, A.; Novellino, E.; Morgante, E.; DI STEFANO, C.; Catalano, G.; Filomeni, G.; Abruzzese, E.; Ciriolo, M. R.; Russo, M.; Amadori, S.; Birilli, R.; LA TORRE, F.; SINIBALDI SOLIMEI, P.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 49:(2006), pp. 5840-5844. [10.1021/jm0602716]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238618
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 62
social impact