Novel star-branched polymers were synthesized by ring-opening polymerization of e-caprolactone (CL) with tetraethylenepentamine (TEPA) as polyfunctional initiator. Different [CL]/[TEPA] molar ratios were used. A branched polymer having five arms and a DPn,exp@DPn,teor was obtained only for [CL]/[TEPA]=50 ratio. The TPCLs were employed to prepare nanoparticles on which a model antibiotic was adsorbed. The significant amount of drug adsorbed onto TPCL50 opens interesting perspectives for the use of this system in the drug delivery field.
Synthesis and properties of star-branched polymers for pharmaceutical applications / F., Micozzi; Crisante, Fernanda; Taresco, Vincenzo; Francolini, Iolanda; Martinelli, Andrea; D'Ilario, Lucio; Piozzi, Antonella. - STAMPA. - (2011), pp. 633-636. (Intervento presentato al convegno XX Convegno di Scienza e Tecnologia delle Macromolecole tenutosi a Terni nel 4-8 settembre 2011).
Synthesis and properties of star-branched polymers for pharmaceutical applications
CRISANTE, Fernanda;TARESCO, VINCENZO;FRANCOLINI, IOLANDA;MARTINELLI, Andrea;D'ILARIO, LUCIO;PIOZZI, Antonella
2011
Abstract
Novel star-branched polymers were synthesized by ring-opening polymerization of e-caprolactone (CL) with tetraethylenepentamine (TEPA) as polyfunctional initiator. Different [CL]/[TEPA] molar ratios were used. A branched polymer having five arms and a DPn,exp@DPn,teor was obtained only for [CL]/[TEPA]=50 ratio. The TPCLs were employed to prepare nanoparticles on which a model antibiotic was adsorbed. The significant amount of drug adsorbed onto TPCL50 opens interesting perspectives for the use of this system in the drug delivery field.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
