Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported. Of the 52 patients with influenza-like disease we observed, 37 underwent a real-time PCR evaluation and 21 had a confirmed diagnosis. Of the RT-PCR-confirmed cases, 23.8% were children (age <18 years) and 9.5% were >65 years; 47.6% presented with a pulmonary infiltrate and 33.3% with respiratory failure. Pulmonary involvement was observed more frequently in patients with comorbidities. All patients received a course of oseltamivir therapy starting an average of 1 day (range <1-2) after the onset of symptoms. No patient was transferred to the intensive care unit. The viral disease had a generally favorable outcome despite the high frequency of pulmonary involvement. A prompt clinical evaluation with an early antiviral and supportive therapy may have played a beneficial role in the outcome. © 2011 S. Karger AG, Basel.
Management of the 2009 A/H1N1 influenza pandemic in patients with hematologic diseases: A prospective experience at an Italian Center / Corrado, Girmenia; Caterina, Mercanti; Vincenzo, Federico; Massimiliano, Rea; Annalisa De, Vellis; Veronica, Valle; Micozzi, Alessandra; Roberto, Latagliata; Massimo, Breccia; Salvatore Giacomo, Morano; Gregorio Antonio, Brunetti; Michela, Sali; Giovanni, Delogu; Foa, Roberto; Alimena, Giuliana; Gentile, Giuseppe. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 126:1(2011), pp. 1-7. [10.1159/000323713]
Management of the 2009 A/H1N1 influenza pandemic in patients with hematologic diseases: A prospective experience at an Italian Center
MICOZZI, Alessandra;Massimo Breccia;FOA, Roberto;ALIMENA, Giuliana;GENTILE, Giuseppe
2011
Abstract
Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported. Of the 52 patients with influenza-like disease we observed, 37 underwent a real-time PCR evaluation and 21 had a confirmed diagnosis. Of the RT-PCR-confirmed cases, 23.8% were children (age <18 years) and 9.5% were >65 years; 47.6% presented with a pulmonary infiltrate and 33.3% with respiratory failure. Pulmonary involvement was observed more frequently in patients with comorbidities. All patients received a course of oseltamivir therapy starting an average of 1 day (range <1-2) after the onset of symptoms. No patient was transferred to the intensive care unit. The viral disease had a generally favorable outcome despite the high frequency of pulmonary involvement. A prompt clinical evaluation with an early antiviral and supportive therapy may have played a beneficial role in the outcome. © 2011 S. Karger AG, Basel.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.