We report the case of a young hemophilic patient with antibodies against the human immunodeficiency virus (HIV) who was affected by immune thrombocytopenic purpura (ITP). This condition did not respond to pharmacological therapy with steroids and alpha-2b-r-IFN, and the patient was splenectomized. Immune status evaluation was performed before and after surgery and during follow-up with CD4-CD8 monoclonal antibodies and cytofluorimetric analysis in order to explore possible correlations between splenectomy and the cytologic immune regulatory system. Splenectomy resulted in a resolution of ITP with consequent disappearance of the hemorrhagic diathesis related to thrombocytopenia. Moreover, at 30 months from splenectomy the patient is still in remission, his CD4 count is not decreased, and no progression to AIDS has been evidenced. These aspects are analyzed and briefly discussed.
SPLENECTOMY OUTCOME IN A HAEMOPHILIC PATIENT WITH HIV- RELATED AUTOIMMUNE THROMBOCYTOPENIA / Dragoni, F.; Arcieri, R.; Chistolini, A.; De Sanctis, V.; Pasqualetti, D.; Mazzucconi, Maria Gabriella. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 78:(1993), pp. 61-63.
SPLENECTOMY OUTCOME IN A HAEMOPHILIC PATIENT WITH HIV- RELATED AUTOIMMUNE THROMBOCYTOPENIA
A. Chistolini;V. De Sanctis;MAZZUCCONI, Maria Gabriella
1993
Abstract
We report the case of a young hemophilic patient with antibodies against the human immunodeficiency virus (HIV) who was affected by immune thrombocytopenic purpura (ITP). This condition did not respond to pharmacological therapy with steroids and alpha-2b-r-IFN, and the patient was splenectomized. Immune status evaluation was performed before and after surgery and during follow-up with CD4-CD8 monoclonal antibodies and cytofluorimetric analysis in order to explore possible correlations between splenectomy and the cytologic immune regulatory system. Splenectomy resulted in a resolution of ITP with consequent disappearance of the hemorrhagic diathesis related to thrombocytopenia. Moreover, at 30 months from splenectomy the patient is still in remission, his CD4 count is not decreased, and no progression to AIDS has been evidenced. These aspects are analyzed and briefly discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
