The ability of fluconazole, a bis-triazole antifungal agent, to inhibit conversion of Candida albicans from the yeast (Y) to the pathogenic mycelial (M) form was studied under various in vitro cultural conditions. In growth-supporting media, fluconazole was able to inhibit Y to M conversion of the test organism at concentrations below those required to inhibit Y phase growth. Under nongrowth-supporting conditions (N-acetylglucosamine solution) fluconazole had only a small effect on Y to M conversion.
THE INHIBITORY-ACTION OF FLUCONAZOLE ON YEAST-TO-MYCELIAL PHASE CONVERSION IN CANDIDA-ALBICANS / Simonetti, Nicola; D'Auria, Felicia Diodata; Strippoli, Vittorio; Simonetti, Giovanna. - In: DRUG INVESTIGATION. - ISSN 0114-2402. - 4:(1992), pp. 15-19.
THE INHIBITORY-ACTION OF FLUCONAZOLE ON YEAST-TO-MYCELIAL PHASE CONVERSION IN CANDIDA-ALBICANS
SIMONETTI, Nicola;D'AURIA, Felicia Diodata;STRIPPOLI, Vittorio;SIMONETTI, Giovanna
1992
Abstract
The ability of fluconazole, a bis-triazole antifungal agent, to inhibit conversion of Candida albicans from the yeast (Y) to the pathogenic mycelial (M) form was studied under various in vitro cultural conditions. In growth-supporting media, fluconazole was able to inhibit Y to M conversion of the test organism at concentrations below those required to inhibit Y phase growth. Under nongrowth-supporting conditions (N-acetylglucosamine solution) fluconazole had only a small effect on Y to M conversion.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
