CDP-Colina: studio dose-effetto sulla sensibilità al contrasto in pazienti glaucomatosi.

Purpose: To evaluate the effects of various doses of oral citicoline on a psycho-physical parameter connected with glaucomatous damage. Materials and Methods: Thirty-nine patients with open-angle glaucoma and a mild-advanced glaucomatous damage were recruited ( mean age 67.9; range 47-86 years). The patients were subdivided in 3 groups according to the type of treatment ( 400, 800 or 1200 mg/day). Another group of 12 untreated patients was the control group. Contrast sensivity was measured in each patient with Vistech VCTS 6000 system (Vistech Consultants Inc. Ohio USA) at baseline, at the end of the tretment, after 2 and 4 months of wash-out. The data were expressed like area under curve of contrast sensitivity ( AUC ) and processed by an analysis of variance. Results: After two months of treatment with citicoline an increase of 15% of the AUC values ( P< 0.001 ) is observed. This improvement already diminishes after 2 months of wash-out ( variation compared to baseline + 10%, P=NS) and practically it get exausted after 4 months of wash-out ( variation compared to baseline +4%; P=NS). Conclusions: Oral citicoline induces a temporary dose-dependent improvement of the contrast sensitivity in patients with glaucoma.