Previous data indicate that the injection of dopaminergic drugs induces changes in cerebellar 3',5'-guanosine monophosphate (cGMP) content. Accordingly, we have investigated the effects of haloperidol, sulpiride, or apomorphine on cerebellar prostaglandin (PG) concentration, a parameter related to cGMP content. Results obtained show that dopamine receptor blocking agents, such as haloperidol and sulpiride, significantly decrease cerebellar PGE2 and PGF2 alpha concentrations, while opposite changes are induced by apomorphine, a dopamine receptor agonist.

Effects of dopaminergic drugs on cerebellar prostaglandin concentrations / C., Millia; Nicoletti, Ferdinando; A. A., Grasso; F., Patti; D. F., Condorelli; E., Rapisarda; L., Rampello; G., Costa; U., Scapagnini. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 41:4(1983), pp. 1190-1191.

Effects of dopaminergic drugs on cerebellar prostaglandin concentrations.

NICOLETTI, Ferdinando;
1983

Abstract

Previous data indicate that the injection of dopaminergic drugs induces changes in cerebellar 3',5'-guanosine monophosphate (cGMP) content. Accordingly, we have investigated the effects of haloperidol, sulpiride, or apomorphine on cerebellar prostaglandin (PG) concentration, a parameter related to cGMP content. Results obtained show that dopamine receptor blocking agents, such as haloperidol and sulpiride, significantly decrease cerebellar PGE2 and PGF2 alpha concentrations, while opposite changes are induced by apomorphine, a dopamine receptor agonist.
1983
animals; apomorphine; brain; dinoprost; dinoprostone; drug effects/metabolism; haloperidol; inbred strains; male; metabolism; pharmacology; prostaglandins; prostaglandins e; prostaglandins f; rats; sulpiride
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of dopaminergic drugs on cerebellar prostaglandin concentrations / C., Millia; Nicoletti, Ferdinando; A. A., Grasso; F., Patti; D. F., Condorelli; E., Rapisarda; L., Rampello; G., Costa; U., Scapagnini. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 41:4(1983), pp. 1190-1191.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/465887
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact