[4]Heterohelicenium cations 1a–c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations 1a–c have been resolved by HPLC using water-based eluents containing KPF6 as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte structure on retention and enantioselectivity was investigated.
Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents / Villani, Claudio; B., Laleau; Pierre, Mobian; Jerome, Lacour. - In: CHIRALITY. - ISSN 0899-0042. - STAMPA. - 19:8(2007), pp. 601-606. [10.1002/chir.20345]
Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents
VILLANI, Claudio;
2007
Abstract
[4]Heterohelicenium cations 1a–c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations 1a–c have been resolved by HPLC using water-based eluents containing KPF6 as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte structure on retention and enantioselectivity was investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
