Natural killer (NK) cells are a particular lymphocyte subset with a documented cytotoxic activity against cancer cells. Evidence of NK antitumoral effect led researchers to focus on the development of immunotherapies aimed at augmenting NK recruitment and infiltration into tumor and their anti-cancer functions. Studies in animal models proved that the right combination of drugs, cytokines, chemokines and other factors might be used to enhance or suppress tumor targeting by NK cells. Therefore, it would be necessary to have a tool to non-invasively monitor the efficacy of such novel therapies. Available imaging techniques comprise magnetic resonance, optical and nuclear medicine imaging with a pool of compounds that ranges from radiolabelled nanoparticles and radiopharmaceuticals to fluorescent probes. Each tracer and technique has its own pros and cons, but till now, no one emerged as superior among the others.

NK cell imaging by in vitro and in vivo labelling approaches / Galli, Filippo; Histed, S; Aras, O.. - In: THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1824-4785. - STAMPA. - 58:3(2014), pp. 276-283.

NK cell imaging by in vitro and in vivo labelling approaches

GALLI, FILIPPO;
2014

Abstract

Natural killer (NK) cells are a particular lymphocyte subset with a documented cytotoxic activity against cancer cells. Evidence of NK antitumoral effect led researchers to focus on the development of immunotherapies aimed at augmenting NK recruitment and infiltration into tumor and their anti-cancer functions. Studies in animal models proved that the right combination of drugs, cytokines, chemokines and other factors might be used to enhance or suppress tumor targeting by NK cells. Therefore, it would be necessary to have a tool to non-invasively monitor the efficacy of such novel therapies. Available imaging techniques comprise magnetic resonance, optical and nuclear medicine imaging with a pool of compounds that ranges from radiolabelled nanoparticles and radiopharmaceuticals to fluorescent probes. Each tracer and technique has its own pros and cons, but till now, no one emerged as superior among the others.
2014
Animals; Cell Tracking; Humans; Isotope Labeling; Killer Cells, Natural; Neoplasms; Radiopharmaceuticals; T-Lymphocytes; Tomography, Emission-Computed
01 Pubblicazione su rivista::01a Articolo in rivista
NK cell imaging by in vitro and in vivo labelling approaches / Galli, Filippo; Histed, S; Aras, O.. - In: THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1824-4785. - STAMPA. - 58:3(2014), pp. 276-283.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/813403
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