The aim of this work is to compare the physicochemical properties of three oligonucleotidic sequences, d(TGGGT), d(TGGGGT) and d(TGGGGGT), which assemble to form quadruplex structures with the same molecularity, but containing three, four, and five G-quartets, respectively. The addition of one or two G-tetrads greatly increases both the enthalpy and Tm values of the quadruplex dissociation.

Relative stability of quadruplexes containing different number of G-tetrads / Petraccone, Luigi; E., Erra; I., Duro; Esposito, Veronica; Randazzo, Antonio; Mayol, Luciano; C. A., Mattia; Barone, Guido; Giancola, Concetta. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 24:5-7(2005), pp. 757-760. [10.1081/NCN-200060080]

Relative stability of quadruplexes containing different number of G-tetrads

PETRACCONE, LUIGI;ESPOSITO, VERONICA;RANDAZZO, ANTONIO;MAYOL, LUCIANO;BARONE, GUIDO;GIANCOLA, CONCETTA
2005

Abstract

The aim of this work is to compare the physicochemical properties of three oligonucleotidic sequences, d(TGGGT), d(TGGGGT) and d(TGGGGGT), which assemble to form quadruplex structures with the same molecularity, but containing three, four, and five G-quartets, respectively. The addition of one or two G-tetrads greatly increases both the enthalpy and Tm values of the quadruplex dissociation.
2005
Relative stability of quadruplexes containing different number of G-tetrads / Petraccone, Luigi; E., Erra; I., Duro; Esposito, Veronica; Randazzo, Antonio; Mayol, Luciano; C. A., Mattia; Barone, Guido; Giancola, Concetta. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 24:5-7(2005), pp. 757-760. [10.1081/NCN-200060080]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/201001
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 15
social impact