Irradn. of trazodone at 310 nm in water has been investigated. In addn. to the OH-substitution in the chlorobenzene ring a peculiar dimerization of the dihydropyridine moiety leading to a cage-like product was involved in the photo-induced modification of the drug. The photoproducts, isolated by chromatog. techniques, have been identified by spectroscopic means. Further support of the structure of the cage-like product was sought by a comparison between the exptl. chem. shifts and the values computed at the DFT level.
Phototransformation of the drug trazodone in aqueous solution / DELLA GRECA, Marina; Iesce, MARIA ROSARIA; Previtera, Lucio; M., Rubino; Barone, Vincenzo; Crescenzi, Orlando. - In: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY. A, CHEMISTRY. - ISSN 1010-6030. - STAMPA. - 199:2-3(2008), pp. 353-357. [10.1016/j.jphotochem.2008.06.018]
Phototransformation of the drug trazodone in aqueous solution
DELLA GRECA, MARINA;IESCE, MARIA ROSARIA;PREVITERA, LUCIO;BARONE, VINCENZO;CRESCENZI, ORLANDO
2008
Abstract
Irradn. of trazodone at 310 nm in water has been investigated. In addn. to the OH-substitution in the chlorobenzene ring a peculiar dimerization of the dihydropyridine moiety leading to a cage-like product was involved in the photo-induced modification of the drug. The photoproducts, isolated by chromatog. techniques, have been identified by spectroscopic means. Further support of the structure of the cage-like product was sought by a comparison between the exptl. chem. shifts and the values computed at the DFT level.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
