Reaction of 5′-0-(4,4′-dimethoxytriphenylmethyl)-3′-deoxythy-midine with triphenylphosphine/carbon tetrachloride, followed by deprotection of the 5′-hydroxyl group, afforded the 4-chloro derivative 3 from which some 4-substituted pyrimidin-2(1H)one-2′, 3′-dideoxyribosides were obtained by nucleo-philic substitution under very mild conditions.
Synthesis of 4-Substituted Pyrimidine 2′,3′-Dideoxynucleosides / DE NAPOLI, Lorenzo; A., Messere; Montesarchio, Daniela; Piccialli, Gennaro; C., Santacroce. - In: NUCLEOSIDES & NUCLEOTIDES. - ISSN 0732-8311. - ELETTRONICO. - 10:8(1991), pp. 1719-1728. [10.1080/15257779108043057]
Synthesis of 4-Substituted Pyrimidine 2′,3′-Dideoxynucleosides
DE NAPOLI, LORENZO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;
1991
Abstract
Reaction of 5′-0-(4,4′-dimethoxytriphenylmethyl)-3′-deoxythy-midine with triphenylphosphine/carbon tetrachloride, followed by deprotection of the 5′-hydroxyl group, afforded the 4-chloro derivative 3 from which some 4-substituted pyrimidin-2(1H)one-2′, 3′-dideoxyribosides were obtained by nucleo-philic substitution under very mild conditions.File in questo prodotto:
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