Bacteriocin DNA nanocomplexes as immunotherapeutic carriers

Date
2012-05
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Abstract Book 2012, 10th CIMT Annual Meeting
Print ISSN
Electronic ISSN
Publisher
Association for Cancer Immunotherapy
Volume
Issue
Pages
136 - 137
Language
English
Journal Title
Journal ISSN
Volume Title
Series
Abstract

Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides (CpG motifs) are clinical candidates as anti-cancer agents, immune adjuvants, anti-allergens, and stand alone immunoprotective agents. Two different classes of CpG-ODNs were identified for clinical applications. B-Class ODNs, also known as K-type CpG ODN, have phosphorothioate backbones and potent B- cell activators. A-Class ODNs (or D-type ODNs) have mixed backbone and flanking G-runs at their 3`and 5-ends.

Course
Other identifiers
Book Title
Keywords
Citation
Published Version (Please cite this version)