Parasites and individual major histocompatibility complex diversity—an optimal 
choice?

Wegner, K. Mathias; Kalbe, Martin; Schaschl, Helmut; Reusch, Thorsten B. H.

doi:doi:10.1016/j.micinf.2004.05.025

Item

ITEM ACTIONSEXPORT

Add to Basket

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_1507164_2

DetailsSummary

Released

Journal Article

Parasites and individual major histocompatibility complex diversity—an optimal choice?

MPS-Authors

/persons/resource/persons56989

Wegner, K. Mathias
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons56756

Kalbe, Martin
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons56904

Schaschl, Helmut
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons56884

Reusch, Thorsten B. H.
Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Wegner, K. M., Kalbe, M., Schaschl, H., & Reusch, T. B. H. (2004). Parasites and individual major histocompatibility complex diversity—an optimal choice? Microbes and Infection, 6(12), 1110-1116. doi:doi:10.1016/j.micinf.2004.05.025.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-DA7E-5

Abstract

Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges.