Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity

MPG-Autoren
/persons/resource/persons56653

Domazet-Lošo,  Tomislav
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)

Hemmrich_2012.pdf
(Verlagsversion), 2MB

Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Hemmrich, G., Khalturin, K., Boehm, A.-M., Puchert, M., Anton-Erxleben, F., Wittlieb, J., et al. (2012). Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Molecular Biology and Evolution, 29(11), 3267-3280. doi:10.1093/molbev/mss134.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0010-20E9-C
Zusammenfassung
How distinct stem cell populations originate and whether there is a clear stem cell “genetic signature” remain poorly understood.
Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position.
In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set
of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication.
Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal
and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common,
multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.