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Novel (bio)chemical and (photo)physical probes for imaging live cells

MPS-Authors
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Jares-Erijman,  E. A.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Spagnuolo,  C.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Bossi,  M.
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

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Lidke,  D. S.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Post,  J. N.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Vermeij,  R. J.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Heintzmann,  R.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Lidke,  K. A.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Arndt-Jovin,  D. J.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Jovin,  T. M.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Jares-Erijman, E. A., Spagnuolo, C., Giordano, L., Etchehon, M., Kawior, J., Manalich-Arana, M. V., et al. (2004). Novel (bio)chemical and (photo)physical probes for imaging live cells. In G. Pifat-Mrzljak (Ed.), Supramolecular structure and function 8. Proceedings of the 8. Int. Summer School on Biophysics: Supramolecular structure and function, Sept. 14 - 26, 2003, Rovinj, Croatia (pp. 99-118). Amsterdam: Kluwer.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-EEB8-8
Abstract
Emerging technologies, utilizing a combination of chemistry, physics and molecular biology, are creating an increasing interest in smart materials serving as reporters and sensors in micro- and nano-systems. Such devices constitute unique tools for a plethora of biological applications and therapies, allowing in vivo and real time monitoring of biomolecular structure and function. Imaging live cells poses a number of problems, not the least of which is to minimize the perturbation of the physiological state and viability of the cells with the probes and "tools". One seeks to achieve single molecule sensitivity (when appropriate and desirable), monitor fast kinetic processes, and observe molecular interactions occurring on distance scales far beyond the optical resolution of light microscopes. In the remainder of this contribution we discuss a few methods that have already attained some of these goals and present some model systems that hold the promise for achieving others. (excerpt from Section 2, this article contains no abstract)