English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Calculating as many fluxes as possible in underdetermined metabolic networks

MPS-Authors
/persons/resource/persons86189

Klamt,  S.
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Klamt, S., & Schuster, S. (2002). Calculating as many fluxes as possible in underdetermined metabolic networks. Molecular Biology Reports, 29(1-2), 243-248. doi:10.1023/A:1020394300385.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-A0C1-F
Abstract
A frequently occurring problem in Metabolic Flux Analysis is that the linear equation systems are underdetermined. A procedure for determining which reaction velocities can be calculated in underdetermined metabolic systems from measured rates and computing these velocities is given. The method is based on the null-space matrix to the stoichiometry matrix corresponding to the reactions with unknown velocities. Moreover, an elementary representation of the null-space is presented. This representation enables one to find those sets of measurable velocities that allow calculation of a certain non-measurable rate. The approach is illustrated by an example from monosaccharide metabolism. © Copyright 2008 Elsevier B.V., All rights reserved. [accessed 2013 June 13th]