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In vivo 1H Spectroscopy of the Caudate Nucleus in Macaca mulatta brain

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Juchem,  C
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Augath,  MA
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Juchem, C., Augath, M., Merkle, H., Logothetis, N., & Pfeuffer, J. (2002). In vivo 1H Spectroscopy of the Caudate Nucleus in Macaca mulatta brain. Poster presented at 19th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2002), Cannes, France.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-DF58-C
Abstract
The neostriatum is important for the control of movement and certain cognitive functions [1]. Loss of striatal neurons or degeneration of the dopaminergic nigrostriatal pathway leads to devastating neurologic disorders. Recent studies about the reduction of Parkinson symptoms in primats [2,3] demonstrate the value of in vivo study of striatal neurochemistry. Here we present a pilot MRS study in monkeys, in which we conducted in vivo measurements of metabolite concentrations of a 0.7cc voxel positioned in the caudate nucleus of a macaque monkey. Our general aim is to combine this methodology with other invasive techniques, such as microdialysis or electrophysiology in order to couple the macroscopic changes visualized with MRS with their underlying neurophysiological events.