Measuring the mass, density, and size of particles and cells using a suspended 
microchannel resonator.

Godin, M.; Bryan, A. K.; Burg, T. P.; Babcock, K.; Manalis, S. R.

doi:10.1063/1.2789694

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Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator.

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Burg, T. P.
Research Group of Biological Micro- and Nanotechnology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Godin, M., Bryan, A. K., Burg, T. P., Babcock, K., & Manalis, S. R. (2007). Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator. Applied Physics Letters, 91(12): 123121. doi:10.1063/1.2789694.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-9C70-8

Abstract

We demonstrate the measurement of mass, density, and size of cells and nanoparticles using suspended microchannel resonators. The masses of individual particles are quantified as transient frequency shifts, while the particles transit a microfluidic channel embedded in the resonating cantilever. Mass histograms resulting from these data reveal the distribution of a population of heterogeneously sized particles. Particle density is inferred from measurements made in different carrier fluids since the frequency shift for a particle is proportional to the mass difference relative to the displaced solution. We have characterized the density of polystyrene particles, Escherichia coli, and human red blood cells with a resolution down to 10−4 g/cm3.