Struggling to let go: A non‐coding RNA directs its own extension and destruction

Bernecky, C.; Cramer, P.

doi:10.1038/emboj.2013.36

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Struggling to let go: A non‐coding RNA directs its own extension and destruction

MPS-Authors

/persons/resource/persons127020

Cramer, P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

External Resource

http://emboj.embopress.org/content/32/6/771
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

1922717.pdf
(Publisher version), 83KB

Supplementary Material (public)

There is no public supplementary material available

Citation

Bernecky, C., & Cramer, P. (2013). Struggling to let go: A non‐coding RNA directs its own extension and destruction. EMBO Journal, 32(6), 771-772. doi:10.1038/emboj.2013.36.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-3C73-E

Abstract

In addition to its role in DNA-dependent transcription, RNA polymerase II (Pol II) possesses RNA-dependent RNA polymerase (RdRP) activity (Lehmann et al, 2007). In a study published in this issue of The EMBO Journal, Wagner et al (2013) report the first native cellular function of the RdRP activity of Pol II. The authors find that a mammalian non-coding RNA (ncRNA) can serve as a template for its own extension by Pol II, resulting in its destabilization and a decrease in its potency to repress Pol II.