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High-probability uniquantal transmission at excitatory synapses in barrel cortex

MPG-Autoren
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Sakmann,  Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Feldmeyer,  Dirk
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

http://science.sciencemag.org/content/302/5652/1981.full-text.pdf+html
(beliebiger Volltext)

https://dx.doi.org/10.1126/science.1087160
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Zitation

Silver, R. A., Lübke, J. H. R., Sakmann, B., & Feldmeyer, D. (2003). High-probability uniquantal transmission at excitatory synapses in barrel cortex. Science, 302(5652), 1981-1984. doi:10.1126/science.1087160.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-115C-A
Zusammenfassung
The number of vesicles released at excitatory synapses and the number of release sites per synaptic connection are key determinants of information processing in the cortex, yet they remain uncertain. Here we show that the number of functional release sites and the number of anatomically identified synaptic contacts are equal at connections between spiny stellate and pyramidal cells in rat barrel cortex. Moreover, our results indicate that the amount of transmitter released per synaptic contact is independent of release probability and the intrinsic release probability is high. These properties suggest that connections between layer 4 and layer 2/3 are tuned for reliable transmission of spatially distributed, timing-based signals.