Molecular Classification of Ependymal Tumors across All CNS Compartments, 
Histopathological Grades, and Age Groups

Pajtler, K. W.; Witt, H.; Sill, M.; Jones, D. T.; Hovestadt, V.; Kratochwil, F.; Wani, K.; Tatevossian, R.; Punchihewa, C.; Johann, P.; Reimand, J.; Warnatz, H.-J.; Ryzhova, M.; Mack, S.; Ramaswamy, V.; Capper, D.; Schweizer, L.; Sieber, L.; Wittmann, A.; Huang, Z.; van Sluis, P.; Volckmann, R.; Koster, J.; Versteeg, R.; Fults, D.; Toledano, H.; Avigad, S.; Hoffman, L. M.; Donson, A. M.; Foreman, N.; Hewer, E.; Zitterbart, K.; Gilbert, M.; Armstrong, T. S.; Gupta, N.; Allen, J. C.; Karajannis, M. A.; Zagzag, D.; Hasselblatt, M.; Kulozik, A. E.; Witt, O.; Collins, V. P.; von Hoff, K.; Rutkowski, S.; Pietsch, T.; Bader, G.; Yaspo, M. L.; von Deimling, A.; Lichter, P.; Taylor, M. D.; Gilbertson, R.; Ellison, D. W.; Aldape, K.; Korshunov, A.; Kool, M.; Pfister, S. M.

doi:10.1016/j.ccell.2015.04.002

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

MPG-Autoren

/persons/resource/persons50625

Warnatz, H.-J.
Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

/persons/resource/persons50655

Yaspo, M. L.
Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

Externe Ressourcen

http://www.ncbi.nlm.nih.gov/pubmed/25965575
(beliebiger Volltext)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Pajtler.pdf
(Verlagsversion), 9MB

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Pajtler, K. W., Witt, H., Sill, M., Jones, D. T., Hovestadt, V., Kratochwil, F., et al. (2015). Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer Cell, 27(5), 728-743. doi:10.1016/j.ccell.2015.04.002.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-58F0-9

Zusammenfassung

Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.