1997-02-14
The correlation of CA15.3 and TPS with tumor course in patients with metastatic breast cancer
Publication
Publication
Journal of Cancer Research and Clinical Oncology , Volume 123 - Issue 2 p. 128- 132
Purpose: This study was performed to determine the correlation of CA15.3 and TPS with disease course in patients with metastatic breast cancer. Methods: Levels of CA15.3 and tissue polypeptide antigen using the M 3 monoclonal antibody (TPS) were determined in the serum of 60 patients with metastatic breast cancer. CA15.3 and TPS were measured at two assay times. Results: A change of more than 25% in the serum level of CA15.3 or TPS was highly correlated with tumor response. The association between response and change in marker levels was stronger for CA15.3 (P = 0.0001) than for TPS (P = 0.0005). Distinct mismatches between marker changes and the tumor response were observed for both CA15.3 and TPS. Conclusion: CA15.3 and TPS are useful in the determination of response to treatment. Because of observed disagreement, marker changes can only be regarded as indicative of disease course.
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| doi.org/10.1007/BF01269892, hdl.handle.net/1765/73507 | |
| Journal of Cancer Research and Clinical Oncology | |
| Organisation | Department of Medical Oncology |
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Pronk, L., Stoter, G., van Putten, W., & de Wit, R. (1997). The correlation of CA15.3 and TPS with tumor course in patients with metastatic breast cancer. Journal of Cancer Research and Clinical Oncology, 123(2), 128–132. doi:10.1007/BF01269892 |
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