I. Development of a recyclable chromium(III) pre-catalyst for chromium-centered transformations ; II. Development of a phenanthroline-based compound for intercalation into DNA and use in biosensors
Development of a recyclable chromium(III) pre-catalyst for chromium-centered transformations
Development of a phenanthroline-based compound for intercalation into DNA and use in biosensors
Thesis (Ph. D.)--University of Rochester. Department of Chemistry, 2015.
Chapter One: Development of a Recyclable Chromium(III) Pre-Catalyst for Chromium-Centered Transformations
The use of chromium in organometallic transformations has become more popular with the advancement of several reactions, namely the Nozaki-Hiyama-Kishi reaction and the Takai olefination. A pre-catalyst was developed that will minimize the expensive and toxic wastes generated during chromium-based organometallic reactions and allows for recovery of the pre-catalyst with no appreciable decline in quality.
Chapter Two: Development of a Phenanthroline-Based Compound for Intercalation into DNA and Use in Biosensors
A phenantholine-based compound was developed with intention to complete a biosensor that would detect if specific DNA analytes are present in a biological sample. We have designed and synthesized a molecule that will bind separately into both DNA and palladium nanoparticles, potentially linking the two binding sites together.
I. Development of a recyclable chromium(III) pre-catalyst for chromium-centered transformations ; II. Development of a phenanthroline-based compound for intercalation into DNA and use in biosensors
