High-speed intravascular photoacoustic imaging at 1.7 μm with a KTP-based OPO

Date
2015-11-01
Language
American English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
The Optical Society
Abstract

Lipid deposition inside the arterial wall is a hallmark of plaque vulnerability. Based on overtone absorption of C-H bonds, intravascular photoacoustic (IVPA) catheter is a promising technology for quantifying the amount of lipid and its spatial distribution inside the arterial wall. Thus far, the clinical translation of IVPA technology is limited by its slow imaging speed due to lack of a high-pulse-energy high-repetition-rate laser source for lipid-specific first overtone excitation at 1.7 μm. Here, we demonstrate a potassium titanyl phosphate (KTP)-based optical parametric oscillator with output pulse energy up to 2 mJ at a wavelength of 1724 nm and with a repetition rate of 500 Hz. Using this laser and a ring-shape transducer, IVPA imaging at speed of 1 frame per sec was demonstrated. Performance of the IVPA imaging system's resolution, sensitivity, and specificity were characterized by carbon fiber and a lipid-mimicking phantom. The clinical utility of this technology was further evaluated ex vivo in an excised atherosclerotic human femoral artery with comparison to histology.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Hui, J., Yu, Q., Ma, T., Wang, P., Cao, Y., Bruning, R. S., … Chen, W. (2015). High-speed intravascular photoacoustic imaging at 1.7 μm with a KTP-based OPO. Biomedical Optics Express, 6(11), 4557–4566. http://doi.org/10.1364/BOE.6.004557
ISSN
2156-7085
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
Biomedical Optics Express
Rights
IUPUI Open Access Policy
Source
PMC
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Final published version
Full Text Available at
This item is under embargo {{howLong}}